Tune it Up is an episode of Anime: Evolution and the first episode not to feature any music soundtrack, score or background music due to the musical talents of the Talentaliens.
Orochimaru joins an intergalactic species of aliens titled Talentaliens who communicate through making thousands of sounds, beatboxing and acapella singing without the use of instruments.
- This episode guest starrs the famous Israel internet-sensations "The VocaPeople" who are known for their extreme talents of singing that simulates instruments playing, along with their white dress and makeup and red lips. The VocaPeople provide the voices for the Talentaliens.
- This is the first episode not to feature any music background.